Programa:

Estrés oxidativo y enfermedades neurodegenerativas

Después de discutir las bases de cada tema les sugiero los siguientes artículos, si ustedes quieren proponer otros solo agreguen la cita en comentarios por favor.

1.       Introducción

Chapter 3

Oxidative Stress and Neurodegenerative Disease

Selva Rivas-Arancibia, Cesar Gallegos-Ríos, Nancy Gomez-Crisostomo, Ever Ferreira-Garcidueñas, et al. 2011

2.       Formación de  radicales libres en el organismo

Free radicals and antioxidants in normal physiological functions and human disease

Marian Valkoa, , , Dieter Leibfritzb, Jan Moncola, Mark T.D. Croninc, Milan Mazura, Joshua Telserd. The International Journal of Biochemistry & Cell Biology

Volume 39, Issue 1, 2007, Pages 44–84

DNA damage by singlet oxygen and cellular protective mechanisms. Lucymara F. Agnez-Lima a,*, Julliane T.A. Melo a, Acarı´zia et al.. Mutation Research 751 (2012) 15–28

3.       Especies reactivas de oxigeno

Free radicals and antioxidants in normal physiological functions and human disease

Marian Valkoa, , , Dieter Leibfritzb, Jan Moncola, Mark T.D. Croninc, Milan Mazura, Joshua Telserd. The International Journal of Biochemistry & Cell Biology

Volume 39, Issue 1, 2007, Pages 44–84

Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease☆

Marc Fransen ⁎, Marcus Nordgren, Bo Wang, Oksana Apanasets. Biochimica et Biophysica Acta 1822 (2012) 1363–1373

4.       Sistemas antioxidantes

Glutathione in Cerebral Microvascular Endothelial. Biology and Pathobiology: Implications for Brain Homeostasis. Wei Li, Carmina Busu,Magdalena L. Circu, and Tak Yee Aw. International Journal of Cell Biology. Volume 2012.

In Utero Oxidative Stress Epigenetically Programs. Antioxidant Defense Capacity and Adulthood Diseases. Rita S. Strakovsky1 and Yuan-Xiang Pan. Antioxidants & Redox Signaling. Volume 17, Number 2, 2012.

Mitochondria: Omega-3 in the route of mitochondrial reactive oxygen species

Kaïs H. Al-Gubory. The International Journal of Biochemistry & Cell Biology 2012

5.       Equilibrio redox en los seres vivos

The control of the balance between ceramide and sphingosine-1-phosphate by

sphingosine kinase: Oxidative stress and the seesaw of cell survival and death

James R. Van Brocklyn ⁎, Joseph B. Williams. Comparative Biochemistry and Physiology, Part B 163 (2012) 26–36

6.       Las especies reactivas como señalizadores en los sistemas biológicos

Hydrogen Sulfide Is a Signaling Molecule and a Cytoprotectant. Hideo Kimura, Norihiro Shibuya, and Yuka Kimura. Antioxidants & Redox Signaling. Volume 17, Number 1, 2012.

7.       Cambios de la señalización en la pérdida aguda del equilibrio redox, estallido respiratorio e infecciones agudas. 

Oxidants, Antioxidants, and the Beneficial Roles of Exercise-Induced Production of Reactive Species. Elisa Couto Gomes,1 Alben´aNunes Silva,2 andMarta Rubino de Oliveira.

Oxidative Medicine and Cellular Longevity. Volume 2012

Redox-Active Antiparasitic Drugs. Chinmay Pal and Uday Bandyopadhyay. Antioxidants & Redox Signaling. Volume 17, Number 4, 2012

8.       Cambios en la señalización de la en los sistemas biológicos por estados crónicos de estrés oxidativo.

Oxidative Stress, DNA Damage, and c-Abl Signaling: At the Crossroad in Neurodegenerative Diseases?  Stefania Gonfloni,1 EmilianoMaiani,1 Claudia Di Bartolomeo,1Marc Diederich,2 and Gianni Cesareni1 International Journal of Cell Biology

Volume 2012.

Protein-oxidized phospholipid interactions in cellular signaling for cell death: From

biophysics to clinical correlations.

Paavo K.J. Kinnunen a,⁎, Kai Kaarniranta b, Ajay K. Mahalka. Biochimica et Biophysica Acta 1818 (2012) 2446–2455

S-Glutathionylation signaling in cell biology: Progress and prospects Anna Pastore a, Fiorella Piemonte. European Journal of Pharmaceutical Sciences 46 (2012) 279–292

9.       Estrés oxidativo y epigenética

The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences. Anthony R. Cyr and Frederick E. Domann. Antioxidants & Redox Signaling

Volume 15, Number 2, 2011

Epigenetic Manifestation of Metabolic Syndrome and Dietary Management

Nidhi Chaudhary,1,* Kiran Kumar Nakka,1,* Nilanjana Maulik,2 and Samit Chattopadhyay. Antioxidants & Redox Signaling. Volume 17, Number 2, 2012.

Gene regulation by melatonin linked to epigenetic phenomena. Ahmet Korkmaz, Sergio Rosales-Corral, Russel J. Reiter. Gene 503 (2012) 1–11

10.   Estrés oxidativo y mitocondria

Mitophagy: A Complex Mechanism of Mitochondrial Removal. Ivana Novak. Antioxidants & Redox Signaling. 2012, 17(5): 794-802. doi:10.1089/ars.2011.4407.

Estrogen and the regulation of mitochondrial structure and function in the brain. Susanne Arnold, Marion Barbara Victor, Cordian Beyer. Journal of Steroid Biochemistry & Molecular Biology 131 (2012) 2– 9

Novel mitochondrial targets for neuroprotection. Miguel A Perez-Pinzon1,5, R Anne Stetler2,3,5 and Gary Fiskum. Journal of Cerebral Blood Flow & Metabolism (2012) 32, 1362–1376.

Transcriptome analysis in mitochondrial disorders. Matthias Elstnera,∗, Douglass M. Turnbul. Brain Research Bulletin 88 (2012) 285– 293

11.   Estado crónico de estrés oxidativo y perdida de regulación del sistema inmune.

Exercise and the aging immune system .Richard J. Simpson∗, Thomas W. Lowder, Guillaume Spielmann, Austin B. Bigley, Emily C. LaVoy, Hawley Kunz. Ageing Research Reviews 11 (2012) 404– 420.

Crosstalk between macrophages and smooth muscle cells in atherosclerotic

vascular diseases. Jun-ichiro Koga, Masanori Aikawa.

Crosstalk of reactive oxygen species and NF-κB signaling. Michael J Morgan, Zheng-gang Liu. Cell Research (2011) 21:103-115

12.   Estado crónico de estrés oxidativo y perdida de regulación de la respuesta inflamatoria

NF-κB signaling pathway and free radical impact. Agnieszka Siomek. Paper in Press, No 2012_284 .Acta Biochimica Polonica Vol. 59, 2012.

13.   Estado crónico de estrés oxidativo y perdida de regulación de la respuesta inflamatoria y su asociación con enfermedades crónico-degenerativas e irreversibles

Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. C Bubici1, S Papa1, K Dean1 and G Franzoso. Oncogene (2006) 25, 6731–674

14.   Estado de estrés oxidativo y plasticidad cerebral

Discusión de varios artículos

15.   Contaminación ambiental, enfermedad  y cerebro

The Adverse Effects of Air Pollution on the Nervous System

Sermin Genc,1 Zeynep Zadeoglulari,1 Stefan H. Fuss,2 and Kursad Genc1 Journal of Toxicology.Volume 2012

Air pollutants: The key stages in the pathway towards the development of cardiovascular disorders. Kohli Shrey, Ahuja Suchit, Dogra Deepika, Krishnan Shruti, Rani Vibha∗

Environmental Toxicology and Pharmacology 3 1 ( 2 0 1 1 ) 1–9

16.   Estado de estrés oxidativo, síndrome metabólico y apolipoproteínas

Crosstalk between macrophages and smooth muscle cells in atherosclerotic

vascular diseases. Jun-ichiro Koga a, Masanori Aikawa. Vascular Pharmacology 57 (2012) 24–28.

Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2

inducers in vascular disease and aging. Sarah J. Chapple, Richard C.M. Siow, Giovanni E. Mann. The International Journal of Biochemistry & Cell Biology 44 (2012) 1315– 1320

Roles of Hydrogen Sulfide in the Pathogenesis of Diabetes Mellitus and Its Complications. Csaba Szabo. Antioxidants & Redox Signaling. Volume 17, Number 1, 2012

17.   Estado de estrés oxidativo y Enfermedad de Alzheimer

Mitochondrial- and Endoplasmic Reticulum-Associated Oxidative Stress in Alzheimer’s Disease: FromPathogenesis to Biomarkers. E. Ferreiro, I. Baldeiras. L. Ferreira, R. O. Costa,. C. Rego, C. F. Pereira, and Oliveira. International Journal of Cell Biology

Volume 2012, 23 pages.

Synaptic Mitochondrial Pathology in Alzheimer’s Disease. Heng Du,1 Lan Guo,1 and Shirley ShiDu Yan. Antioxidants & Redox Signaling. Volume 16, Number 12, 2012

Amyloid-β and Mitochondria in Aging and Alzheimer’s Disease: Implications for

Synaptic Damage and Cognitive Decline. P. Hemachandra Reddya,b,∗, Maria Manczaka, Peizhong Maoa, Marcus J. Calkinsa, Arubala P. Reddya and Ulziibat Shirendeba. Journal of Alzheimer’s Disease 20 (2010) S499–S512

18.   Estado de estrés oxidativo y Enfermedad de Parkinson

The Neuroprotection of Hydrogen Sulfide Against MPTP-Induced Dopaminergic Neuron Degeneration Involves Uncoupling Protein 2 Rather Than ATP-Sensitive Potassium Channels. Ming Lu,1 Fang-Fang Zhao,1 Juan-Juan Tang,1 Cun-Jin Su,1 Yi Fan,1 Jian-Hua Ding, Jin-Song Bian,1,2 and Gang Hu. Antioxidants & Redox Signaling. Volume 17, Number 6, 2012

Mitochondrial Dysfunction in Parkinson’s Disease. Jianhui Zhu and Charleen T. Ch. Journal of Alzheimer’s Disease 20 (2010) S325–S334

19.   Estado de estrés oxidativo y Enfermedad de Huntington

Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration. David A. Patten1, Marc Germain1, Melissa A. Kelly and Ruth S. Slack . Journal of Alzheimer’s Disease 20 (2010) S357–S367

20.   Estado de estrés oxidativo y ELA

21.   Estado de estrés oxidativo y Esclerosis Múltiple

22.   Estado de estrés oxidativo y Cáncer

Mitochondrial remodeling in cancer metabolism and survival: Potential for

new therapies. Inês A. Barbosa a, Nuno G. Machado a, Andrew J. Skildum b, Patricia M. Scott b, Paulo J. Oliveira. Biochimica et Biophysica Acta 1826 (2012) 238–254

23.   Estrés oxidativo y envejecimiento

Consequences of oxidative stress in age-related macular degeneration

Stuart G. Jarrett a, Michael E. Boulton. Molecular Aspects of Medicine 33 (2012) 399–417